The development and optimization of the drug development path is an important part of creating a compelling value story; both the TPP and eNPV are vital tools in this process. The eNPV metric allows organizations to align business drivers with the product goal. The next step is the choice of the development path, which relies on trade-offs. Once these factors have been determined, the final step is persuading the stakeholders to agree on the right path by using informed and data-driven decisions.